Symposium on Medical Diseases and Molecular Biology. 2. Contributions of Molecular Biology to Neurology.

A Symposium on Molecular Biology

pharmacology, clinical, toxicity, and site of action where known. In some instances, the mode of action of the drug is also given but this is of course a futile section in view of our ignorance on this subject. References are given throughout the discussion of each drug. This handbook is satisfactory for a neophyte in this field; for the physician or for the intensive investigator, the discussi...

JMMB Symposium on Spirochete Molecular Biology

In this review we describe several genetic regulatory mechanisms adopted by the agent of Lyme disease, Borrelia burgdorferi, to sense and adapt to different host and environmental conditions either in vitro or in vivo. This regulation results in the increased or decreased synthesis of several proteins whose levels are believed to play key roles in the ability of B. burgdorferi to cycle between ...

Symposium: Nutrition, Biochemisty and Molecular Biology of Biotin Molecular Biology of Biotin Attachment to Proteins

Enzymatic attachment of biotin to proteins requires the interaction of a distinct domain of the acceptor protein (the “biotin domain”) with the enzyme, biotin protein ligase, that catalyzes this essential and rare post-translational modification. Both biotin domains and biotin protein ligases are very strongly conserved throughout biology. This review concerns the protein structures and mechani...

Algorithmic Contributions to Computational Molecular Biology

Molecular biology of prion diseases.

Prions cause transmissible and genetic neurodegenerative diseases, including scrapie and bovine spongiform encephalopathy of animals and Creutzfeldt-Jakob and Gerstmann-Sträussler-Scheinker diseases of humans. Infectious prion particles are composed largely, if not entirely, of an abnormal isoform of the prion protein, which is encoded by a chromosomal gene. A posttranslational process, as yet ...